Select a year 1998 1999 2000 2001 2002 2003    Select a researcher Frederick W. Alt, Ph.D Bruce N. Ames, Ph.D. Spyridon Artavanis-Tsakonas, Ph.D. Giuseppe Attardi, M.D. Steven N. Austad, Ph.D. Tamas Bartfai, Ph. D. Andrzej Bartke, Ph.D. Nir Barzilai, M.D. Seymour Benzer, Ph.D. Seymour Benzer, Ph.D. Helen M. Blau, Ph.D. Roger Brent, Ph. D. Linda B. Buck, Ph. D. Jochen Buck, M.D., Ph.D. Judith Campisi, Ph.D. Luca Cavalli-Sforza, M.D. Catherine F. Clarke, Ph.D., co-PI James E. Cleaver, Ph.D. Stanley N. Cohen, M.D. Gretchen J. Darlington, Ph.D. Titia de Lange, M.D. , Ph.D. Ronald A. DePinho, M.D. Stephen J. Elledge, Ph.D. Art Gafni, Ph.D. Lawrence S.B. Goldstein, Ph.D. Daniel E. Gottschling, Ph.D. Michael E. Greenberg, Ph.D. Paul Greengard, Ph.D. Carol W. Greider, Ph.D. Jack D. Griffith, Ph. D. Leonard Guarente, Ph.D. Philip C. Hanawalt, Ph. D. Stephen Helfand, M.D. Peter J. Hornsby, Ph. D. Thomas E. Johnson, Ph.D. Cynthia J. Kenyon, Ph.D. Cynthia J. Kenyon, Ph.D. Stuart Kim, Ph.D. Thomas Kornberg, Ph. D. Pamela L. Larsen, Ph.D., co-PI Jeff W. Lichtman, M.D., Ph.D. Charles M. Lieber, Ph. D. Susan L. Lindquist, Ph.D. Stuart Lipton, M.D., Ph.D. Gordon Lithgow, Ph.D. Lawrence A. Loeb, M.D., Ph.D. Victoria Lundblad, Ph.D. Mark Mayford, Ph.D. Simon Melov, Ph.D. James F. Nelson, Ph.D. Fernando Nottebohm, Ph.D. Olivia M. Pereira-Smith, Ph.D. Thomas Perls, M.D., M.P.H Gregory A. Petsko, D. Phil. Daniel Promislow, Ph.D. Fred E. Regnier, Ph.D, co-PI Arlan G. Richardson, Ph.D, co-PI David Ron, Ph. D. Gary Ruvkun, Ph.D. Thomas P. Sakmar, M.D. Joshua R. Sanes, Ph.D Jerry W Shay, Ph.D. James L. Sherley, M.D., Ph.D. Sangram S. Sisodia, Ph. D. Rudolph E. Tanzi, Ph.D. David S. Thaler, Ph.D. John Tower, Ph.D. Eric Verdin, M.D. Douglas C. Wallace, Ph.D. Robert A. Weinberg, Ph.D. Sherman M. Weissman, M.D. Phyllis M. Wise, Ph.D. Woodring E. Wright, M.D., Ph.D. Select a project Translating Yeast Telomere Biology to Human Cells: Identi...A High Throughput Screen for Longevity GenesA Novel Class of Aging Genes in Drosophila melanogasterA Novel Proteomic Approach to Identifying, Sequencing, and...Aging in Mutator and Antimutator MiceAging-dependent Large Accumulation of Mutations at Specifi...Analysis of genes that control aging in C. elegansBicarbonate-activated adenylyl cyclase and agingBone Marrow to Brain: Searching for markers of bone marrow...Can the Heat-Shock Response Extend the Lifespan of the Mou...Cell Physiologic Stresses and Telomere-Based Cell SenescenceCell Transplantation Models for Gene Action in Human AgingChronic Neuroprotection during Aging by UCP Mediated Simul...Connections Between the Telomere Sensing and DNA Damage Ac...Critically Testing the Free Radical Theory of Aging, and D...Early Hormonal Signaling and Longevity: Role of Long-term ...Endogenous DNA Damage and Mechanisms of AgingEstradiol is a Neuroprotective Factor in the Aging Brain: ...Exploration of the C.elegans insulin-like aging pathwayExploring the genetics of extreme longevityFunctional Tests of Replicative Aging in Organotypic Skin ...Gene-gene interactions, gene networks and aging in natural...Genes Controlling Longevity in CentenariansGenetic Dissection of Aging in DrosophilaGenetic Mechanisms of Exceptional Oxidative Damage Resista...Genetic Mechanisms Regulating Replicative Aging in Diffier...Genomic approaches to studying aging in C. elegansHow cells die in Alzheimer's and other neurodegenerati...Hypothesis to be tested: some aspects of functional aging ...Identification of Candidate Genes for Longevity in Long Li...Identification of Chemical “Age Spots” on Immortal DNA Str...Identification of gerontogenes in the mouseIdentification of Longevity Genes in Founder PopulationsIdentification of Protein Regulators of Self-renewal, Diff...Intersection of two pathways in control of aging: nutritio...Investigating the Potential Involvement of Cellular Qualit...Life extension genes in DrosophilaMitochondrial Aging in the ChimpanzeeMitochondrial Mutation and AgingMitochondrial swirls, a link between oxidative stress and ...Molecular analysis of mammalian agingMolecular Determinants of Hippocampal Neuroplasticity in a...Molecular through Cellular Changes Responsible for Alzheim...Mutagenic Screen for Longevity Genes in MiceNovel APP - containing synaptic organelles and Alzheimer&#...Probing the role of axonal transport disturbance and trans...Proteotoxicity and AgingRapid Screening for Longevity Mutants in MiceRepair of Oxidative DNA Damage in Human NeuronsReplicative senescence in S. cerevisiaReplicative Senescence of Drosophila Stem Cells in VivoReversal of Mitochondrial Decay: From Rats to HumansRole of a SIRT3, a Sir2-related Mitochondrial Protein Deac...Role of telomeres and telomerase in human agingRole of the multiligand receptor, LRP. In Alzheimer’s dise...Single Molecule Studies of Age-Related Alterations in Heat...Telomere Looping and Control of Cell AgingTelomeres, Cell Phenotype and AgingThe Biology of Mammalian Sir2 Homologs and their Role in L...The Chromophore Regeneration Pathway in Age-related Macula...The Genetic Role of Telomere Dynamics and DNA Damage Respo...The Molecular/Physiological Basis for Accelerated Aging in...The Rapid Identification of Hormones and Pharmacological C...The Role of P13K/Akt Dependent Phosphorylation of a Mammal...The Role of T-loops in Aging of Human CellsThe Role of the MORF/MRG Family of Novel Transcription Fac...The roles of recombination and telomerase in telomere main...Time Lapse Imaging of Neurons as They AgeToward a Comprehensive Assessment of Gene Expression durin...Use of Blood Stem Cells to Regenerate Neurons via the Tran... Select an institution Albert Einstein College of Medicine of Yeshiva University Baylor College of Medicine Boston Medical Center Brandeis University Buck Institute for Age Research Burnham Institute California Institute of Technology Center for Blood Research, Boston Children's Hospital, Boston Children's Hospital, Oakland Research Institute Dana Farber Cancer Institute Fred Hutchinson Cancer Research Center Harvard Medical School Harvard University J. David Gladstone Institutes Johns Hopkins University Lawrence Berkeley National Laboratory Massachusetts General Hospital Massachusetts General Hospital Cancer Center Massachusetts Institute of Technology Molecular Sciences Institute Purdue University Rockefeller University Scripps Research Institute Skirball Institute - New York University School of Medicine Southern Illinois University School of Medicine Stanford University Medical Center Stanford University School of Medicine University of California - Davis University of California - Irvine University of California - Los Angeles University of California - San Diego, Howard Hughes Medical Institute University of California - San Francisco University of California - San Francisco, UCSF Cancer Center University of Chicago University of Colorado - Boulder University of Connecticut Health Center University of Georgia University of Michigan University of North Carolina - Chapel Hill University of Southern California University of Texas Health Science Center - San Antonio University of Texas Southwest Medical Center University of Texas Southwestern Medical Center University of Washington Weill Medical College of Cornell University Whitehead Institute for Biomedical Research Yale University School of Medicine

Mark Mayford, Ph.D. Scripps Research Institute

Generalized aging at the cellular level is thought to arise from the accumulation of damage to protein and nucleic acids that eventually results in the impairment of normal cellular function or transformation of the cells to a cancerous form of growth. How does this damage occur? One hypothesis that is consistent with invertebrate genetic studies as well as with comparative studies of longevity across species is the “free radical theory of aging”. According to this view, it is the oxidative damage to proteins, lipids and DNA caused by free radicals produced during normal metabolic activity that eventually leads to impaired cellular function and aging. Genetic screens in invertebrates such as Drosophila have been successful in identifying mutant animals with up to a twofold increase in longevity and these animals often show increased resistance to oxidative stress. However much less is known about aging in mammals. We propose to employ genetic screens in the mouse to identify mutant animals with increased resistance to or decreased production of free radicals. Mutant animals identified on the basis of altered free radical response will then be analyzed in aging studies to determine whether they show a delay in the onset of various age related disorders and an increase in longevity. The results should provide a test of the free radical theory of aging in mammals and potential therapeutic targets for the numerous age related disorders thought to involve free radical induced cellular damage.

Contact Dr. Mayford.