Stanley
Falkow,
Ph.D.
Stanford University School of Medicine
The Natural History of Typhoid Infection in Vietnam
The goal of the research is to examine the differences in typhoid bacilli causing
acute typhoid fever as compared to the bacteria isolated from chronic typhoid
carriers in Vietnam. One further component of our proposed work will be to
obtain peripheral blood from patients suffering from acute typhoid fever to
determine if there is a distinct pattern of host cell statement in these individuals that
correlates with clinical outcomes. These data can be profitably compared with
in-vitro studies of bacterial interaction with cultured human activated
monocytes-macrophage cell lines.
