Select a year 1998 1999 2000 2001 2002 2003    Select a researcher Shawn Cameron Ahmed, B.S., Ph.D. Yidong Bai, Ph.D. Antonio Bedalov, M.D., Ph.D. Michael J. Bertram, Ph.D. Dominique Broccoli, Ph.D. Cindy X. Cai, M.D., Ph.D. Phillip Carpenter, Ph.D. Sandy Chang, M.D.,Ph.D Phillip A. Cole, M.D., Ph.D Ana Maria Cuervo, M.D., Ph.D. Jay M. Edelberg, Ph. D. Michael D. Ehlers, M.D., Ph.D. Stewart Frankel, Ph.D. Jeffrey S. Friedman, Ph. D. Wen-Biao Gan, Ph. D. Roman Giger, Ph.D. Todd Golde, M.D., Ph.D Vera Gorbunova, Ph.D. Shiv L. S. Grewal, Ph.D. Francine Grodstein, Sc.D. Ming Guo, M.D., Ph.D Ya Ha, Ph.D. Bruce Hay, Ph.D. Yasunori Hayashi, M.D., Ph.D. Mike Hutton, Ph. D. Shin-ichiro Imai, M.D., Ph.D. Michael Gordon Kaplitt, M.D., Ph.D. Tae-Wan Kim, Ph.D. Shuji Kishi, M.D., Ph.D. Steven Lyle, M.D., Ph.D. Jiyan Ma, Ph.D. Kyung-Tai Min, Ph.D. Danesh Moazed, Ph.D. William A. Mohler, Ph.D. Kathryn J. Moore, Ph.D. Elly Nedivi, Ph.D. David K. Orren, Ph. D. Giovanni Paternostro, M.D., Ph.D. Henry L. Paulson, M.D., Ph.D. Jacob Raber, Ph.D. Brad A. Rikke, Ph.D. Jeff J. Sekelsky, Ph. D. Robert Sheaff, Ph.D. Hong-Bing Shu, Ph. D. David A. Sinclair, Ph.D. James E. Sligh, M.D., Ph. D. Zhou Songyang, Ph.D. Peiqing Sun, Ph. D. Marc Tatar, Ph. D. Anthony D. Wagner, Ph. D. David Q.H. Wang, M.D., Ph.D. Weidong Wang, Ph.D. David G. Wells, Ph.D. Stephen Robert Wicks, Ph.D. Huaxi Xu, Ph.D. Hong Yan, Ph.D. Hui Zheng, Ph. D. Select a project A Genetic Approach to Identification of Genes Involved in ...A Mechanistic Explanation for the Development of Neurodege...Age-related Changes in the Functional Neurobiology of MemoryAging and Cholesterol Gallstone Formation: Molecular Mecha...Altered Mitochondrial Function in Transgenic Models of Cut...An Inducible Gene Knockout System for Alzheimer's Dise...ApoptosisBiochemical Characterization of a Putative p53-binding Pro...Characterization of a Novel Protein Complex Involved in th...Chemical Genetic Approaches to AgingConnections Between the Nucleolus and Cellular AgingCPG15, A Novel Growth Promoting Molecule Involved in Synap...Effect of Aging on Efficiency and Accuracy of DNA Double-S...Effect of PTEN Anti-Oncogene on Age-Related Neurodegenerat...Estrogen, Antioxidants, and Cognitive Function in WomenFunctional Analysis of Aging and Cell Survival Signal Path...Functional Characterization of a Drosophila RecQ HelicaseGender and Isoform-Specific Effects of ApoE on Cognition i...Genetic Analysis of Cardiac Aging in DrosophilaGenetic Analysis of the MORF4 Related Gene Family in Droso...Genetic and Functional Analysis of CD36-signaling in Age-r...Genetic and functional analysis of mitochondrial DNA mutat...Genetic Approaches for Functional Aging in ZebrafishGenetic Studies of Factors Controlling Amyloid ProductionGenomic Instability and Aging in Werner-Telomerase Compoun...Germline Immortality in C. elegansGonadal Steroid Regulation of ß-Amyloid Generation: ...Heterochromatin Assembly and Replicative Life-Span in Fiss...Identification of Genes and Compounds that Extend Yeast Li...Identification of Proteins Functionally Redundant to the W...Identifying Regulators of APP gamma-secretaseIn Vivo Analysis of the Role of Tau in Neurodegeneration.In Vivo Study of Age-related Changes in Synaptic StructureInhibition of N-acetyltransferaseLife Extension of Drospohila by a Drug TreatmentMechanisms of Neural Plasticity in the Mammalian SystemMechanisms of Neuronal Dysfunction and Death in Neurodegen...Molecular and Cell Biology of Adult Epithelial Stem CellsMolecular Mechanisms of Age-Related Changes at Hippocampal...Molecular Mechanisms of Telomere Dependent SenescenceNatural Sequence Variation in C. elegans: Impact on...Neuroendocrine Regulation of Aging in DrosophilaNew Approaches to Characterizing Cellular Changes in Sarco...Nuclear Ferritin May Protect Against Oxidative and Light-i...Presenilins and Gamma-Secretase Cleavage of the Amyloid Be...QTLs Specifying the Retardation of Reproductive Senescence...Regulation of Senescent Angiogenic PotentialRestoration of chaperone-mediated autophagy activity in ol...Role of Neural Progenitors in Adult Hippocampal- and Olfac...Signaling by Tumor Necrosis Factor Family MembersStructural studies of human y-secretaseSynaptic Plasticity in the Aging Brain: Role of CPE-depend...The Function of Mammalian NAD-dependent deacetylase Sir2The Pathogenic Mechanism of Prion DiseaseThe Regulation of Chromosomes and LongevityThe Role of p66shc in Cellular Senescence and M...Understanding the Role of Genomic Instability in Human Agi... Select an institution Albert Einstein College of Medicine of Yeshiva University Baylor College of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School Boston College Brigham and Women's Hospital, Harvard Medical School Brown University Burnham Institute California Institute of Technology Cold Spring Harbor Laboratory Columbia University Cornell University Dana Farber Cancer Institute, Harvard Medical School Duke University Medical Center Fox Chase Cancer Center Fred Hutchinson Cancer Research Center Harvard Medical School M.D. Anderson Cancer Center Massachusetts General Hospital Massachusetts Institute of Technology Mayo Clinic, Jacksonville National Institute of Neurological Disorders and Stroke, National Institutes of Health National Institute on Aging, National Institutes of Health National Jewish Medical Center Ohio State University Oregon Health & Science University Rockefeller University Scripps Research Institute Skirball Institute - New York University School of Medicine Stanford University Tufts University School of Medicine University of Alabama - Birmingham University of California - Los Angeles University of Colorado - Boulder University of Connecticut Health Center University of Iowa University of Kentucky Chandler Medical Center University of Minnesota Cancer Center University of North Carolina - Chapel Hill University of Rochester Medical Center University of Texas Health Science Center - San Antonio University of Texas Medical School - Houston Vanderbilt University School of Medicine Washington University School of Medicine Weill Medical College of Cornell University Yale University School of Medicine

Jay M. Edelberg, Ph. D. Cornell University

The focus of our laboratory is to understand the biological basis for the depression of angiogenic activity in the aging heart. Previous studies have revealed that these age-dependent differences in cardiac angiogenesis correlate with the diminished capacity of cardiac microvascular endothelial cells to migrate into new capillary beds. We hypothesize that the senescent-associated depression in cardiac angiogenic potential may be due to altered endothelial cell regulation. To this end, we are studying the senescence-associated changes in the communication pathways governing cardiac endothelial cell activity. We previously demonstrated that cardiac microvascular endothelial gene expression is, in part, regulated by the surrounding cardiac myocytes. Recently, we showed that this communication between cardiac microvascular endothelial cells and cardiac myocytes is mediated by platelet-derived growth factor (PDGF) AB and the PDGF a receptor. The PDGF-dependent pathway induces the endothelial expression of critical angiogenic components, including vascular endothelial growth factor and its receptor, Flk-1. These findings, in conjunction with previous studies by others that have revealed decreased levels of PDGF isoforms and receptors in the aging heart, suggest that alterations in this cardiac microvascular communication may contribute to the depressed angiogenic potential in the senescent heart.

Our present research studies the changes in the microvascular communication in the aging murine heart. Our goal is to identify the molecular and cellular pathways that may contribute to the depression in senescent cardiac endothelial angiogenic activity. Moreover, the results of these studies may offer a foundation for the development of novel cardiovascular therapeutic approaches specifically targeted at the aging heart.

Contact Dr. Edelberg.