 | Leonard Guarente, Ph.D.
Massachusetts Institute of Technology | | Molecular analysis of mammalian aging
1998 Senior Scholar Award in Aging
Dr. Guarente is extending his studies of genetic mechanisms of aging in yeast to
mammals. He intends to determine changes in rDNA that accumulate with age in
mice. He will then generate transgenic mice with specific rDNA changes in order
to test whether specific changes cause aging. |
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 | Elly Nedivi, Ph.D.
Massachusetts Institute of Technology | | CPG15, A Novel Growth Promoting Molecule Involved in Synaptic Plasticity
1998 New Scholar Award in Aging
The capacity of the central nervous system (CNS) to modify connectivity properties as a result of activity is termed plasticity. Plasticity is not only a prominent feature of CNS development, but in the adult brain underlies learning and memory processes and adaptive reorganization of primary sensory maps. In the cases of both... (more) |
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Yasunori Hayashi, M.D., Ph.D.
Massachusetts Institute of Technology | | Role of Neural Progenitors in Adult Hippocampal- and Olfactory Bulb-Dependent Learning and Memory
2001 New Scholar Award in Aging
Recent studies have demonstrated that neural stem cells exist in the adult nervous system of both lower vertebrates and phylogenetically higher
mammalian organisms, including humans. These findings raise the possibility that new neurons continue to be produced naturally in the adult brain even
after... (more) |
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 | Lee Gehrke, Ph.D.
Massachusetts Institute of Technology | | Exploiting an Evolutionary Omission in Pathogenic RNA Viruses: Understanding the Advantages of BeingNon-polyadenylated
2001 Senior Scholar Award in Global Infectious Disease
The identification of features that are pathogen-specific and sensitive to therapeutic
agents is fundamental to treating infectious human diseases. This proposal focuses
on a feature common to a wide range of pathogenic RNA viruses: the absence of
poly(A) tails on the viral... (more) |
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| Leonard Guarente, Ph.D.
Massachusetts Institute of Technology |
 | Douglas C. Wallace, Ph.D.
University of California - Irvine | | Molecular Biology of Aging Summer Course
1999 Summer Course Award in Aging
The Ellison Medical Foundation funded a three-week summer course on the Molecular Biology of Aging at the Marine Biological Laboratory, Woods Hole, MA for the years 1999 through 2001. The course was directed by Drs. Leonard Guarente and Douglas C. Wallace. Funds cover all expenses for attending students (graduate students, post-docs, junior faculty, and senior investigators). Morning lectures in Model Systems (yeast and C. elegans), DNA Mutation and Repair, Telomeres and Cellular Senescence, Mammalian Aging, and Evolutionary Considerations are followed by laboratory exercises.
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Georgia Pangiotakos,
Massachusetts Institute of Technology | | Conference on Infectious Disease
2002 Conferences, Workshops & Education Award in Global Infectious Disease
The Ellison Medical Foundation awarded $4,000 to help support an undergraduate student-organized Conference on Infectious Disease co-sponsored by the Harvard and MIT Hippocratic Societies. The conference was held March 9-10, 2002 at Harvard University and provided a forum for undergraduate students to discuss and examine the ethical, scientific, legal and economic implications of infectious disease with leaders in the field.
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Shugang Zhang, Ph.D.
Massachusetts Institute of Technology | | Second Multidisciplinary Workshop:
2001 Conferences, Workshops & Education Award in Aging
The Ellison Medical Foundation awarded $10,000 to help support the Second Multidisciplinary Workshop: Self-assembling Peptide Systems in Biology, Engineering and Medicine organized by the Center for Biomedical Engineering, Massachusetts Institute of Technology, the Department of Chemistry, Princeton University, and the Center for Self-Organizing Molecular Systems, University of Leeds, UK. The symposium was held July 13-17, 2001 in Crete, Greece |
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Shugang Zhang, Ph.D.
Massachusetts Institute of Technology | | A multidisciplinary workshop: Self-assembling peptide systems in biology, engineering and medicine.
1998 Conferences, Workshops & Education Award in Aging
The primary goal of this workshop is to advance the emerging field of self-assembling peptide systems. This is the first meeting to cover a broad spectrum of fields, including biology, chemistry, physics, protein science, polymer science, materials science, various engineering disciplines, and medical science related to aging under a common theme. It is expected that this meeting will generate novel ideas and collaborations that could produce important scientific breakthroughs in a variety of areas including aging. |
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Shugang Zhang, Ph.D.
Massachusetts Institute of Technology | | Third Multidisciplinary Workshop on Self-assembly of Peptides and Proteins in Biology, Medicine, & Engineering
2003 Conferences, Workshops & Education Award in Aging
The Ellison Medical Foundation awarded $10,000 to help support the Third Multidisciplinary Workshop on Self-assembly of Peptides and Proteins in Biology, Medicine, & Engineering organized by the Center for Biomedical Engineering, Massachusetts Institute of Technology, the Department of Chemistry, Princeton University, and the Center for Self-Organizing Molecular Systems, University of Leeds, UK. The symposium will be held August 1-5, 2003 in Crete, Greece. . Registration deadline – July 1, 2003. For further information, see: http://web.mit.edu/lms/creteworkshop2003/ |
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 | James L. Sherley, M.D., Ph.D.
Massachusetts Institute of Technology | | Identification of Chemical “Age Spots” on Immortal DNA Strands in Adult Stem Cells
2003 Senior Scholar Award in Aging
Modern societies are the beneficiaries of a previous century of extraordinary acceleration of advances in science and medicine. Yet, there is still a significant burden of disease and illness. One reason for the persistence of sickness and poor health is that, despite extensive knowledge of human biology and... (more) |
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 | Alexander Rich, M.D.
Massachusetts Institute of Technology | | Viral Pathogenic Mechanisms Involving Z-DNA Binding Proteins
2003 Senior Scholar Award in Global Infectious Disease
When a virus infects a mammal, a number of different processes occur that determine the success of the viral infection. The host (sometimes a human) immediately mounts an anti-viral response, creating a number of substances that are designed to disarm the virus and prevent it from replicating or producing materials that harm the host.... (more) |
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Georgia Pangiotakos,
Massachusetts Institute of Technology | | 2004 Conference on International Health
2004 Conferences, Workshops & Education Award in Global Infectious Disease
The Ellison Medical Foundation awarded $5,000 to help support an undergraduate student-organized Conference on International Health co-sponsored by the Harvard and MIT Hippocratic Societies. The conference was held February 21-22, 2004 at Harvard University, Cambridge, Massachusetts. For further information, see http://www.hippocraticsociety.org/
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Carlos Lois, M.D., Ph.D.
Massachusetts Institute of Technology | | The Role of Adult Neurogenesis in the Brain of Adult Songbirds: A Transgenic Approach
2004 New Scholar Award in Aging
It is generally assumed that the generation of neurons ceases before or soon after birth, and consequently, that neurons are not replaced in the brain of adult animals. According to this view, neurons are long-lived, such that their synaptic connections are able to encode information over long periods of time.... (more) |
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 | H. Robert Horvitz, Ph.D.
Massachusetts Institute of Technology | | Genetic Control of Aging in C. elegans
2004 Senior Scholar Award in Aging
The roundworm Caenorhabditis elegans has proven to be an excellent organism for genetic studies of longevity, and many genes known to affect lifespan have been identified and characterized in this organism. Nonetheless, much remains to be discovered about the genetic, molecular and cellular bases of aging and longevity. Most studies of C.... (more) |
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