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Nobel Prize Awarded to Linda Buck

Linda B. Buck of the Fred Hutchinson Cancer Research Center will share the 2004 Nobel Prize in Medicine with Richard Axel of the Howard Hughes Medical Institute. Their independent work on the basic biology of the sense of smell led to identification of genes responsible for specific odor receptor proteins and the pathways of olfactory messages between the nose and the brain. The Nobel Prizes will be presented by His Majesty the King of Sweden in Stockholm, Sweden on December 10, 2004.

Buck is in her final year as an Ellison Medical Foundation Senior Scholar in Aging and has been doing research to screen large chemical libraries for compounds that extend lifespan in C. elegans in order to determine the identities of the molecules with which they interact in the organism. Using cutting edge screening tools she is working to identify the multiple processes that can influence aging as well as those that may operate in a subset of cells to exert a higher level "central" control over aging throughout the body, and thus do for longevity genes, what she and Richard Axel did for the biology of olfaction.

For further information, see http://nobelprize.org/medicine/laureates/2004/index.html.